DNA damage lures T cells

Radiation track and DNA damage

lovastatin prevents bleomycin-induced dna damage to hepg2 cells

lovastatin as a member of 3-hydroxy-3-methylglutaryl-coenzyme a (hmg-coa) reductase inhibitors is used as a lipid-lowering agent. it can also inhibit the formation of hydrogen peroxide and superoxide anion and finally leads to decline in oxidative stress processes. here, we evaluated whether lovastatin can increase dna damage resistance of hepg2 cells against genotoxicity of the anticancer drug...

DNA damage in dental pulp mesenchymal stem cells: An in vitro study

The aim of this study was to evaluate the potential use of a DNA comet assay, DNA fragmentation fluorimetric assay and reactive oxygen species levels as potential biomarkers of genome conditions of dental pulp stem cells (DPSCs) isolated from dog canine teeth. Mesenchymal stem cells were isolated from the dental pulp collected from dog teeth. The results obtained suggest the ideal moment for cl...

The Role of chk2 in Response to DNA Damage in Cancer Cells

Accumulation of gene changes and chromosomal instability in response to cellular DNA damage lead to cancer. DNA damage induces cell cycle checkpoints pathways. Checkpoints regulate DNA replication and cell cycle progression, chromatin restructuring, and apoptosis. Checkpoint kinase 2 (chk2) is activated in response to DNA lesions. ATM phosphorylate chk2. The activated Chk2 kinase can phosphoryl...

DNA damage and repair in eukaryotic cells.

DAMAGE IN DNA AFTER IRRADIATION CAN BE CLASSIFIED INTO FIVE KINDS: base damage, single-strand breaks, double-strand breaks, DNA-DNA cross-linking, and DNA-protein cross-linking. Of these, repair of base damage is the best understood. In eukaryotes, at least three repair systems are known that can deal with base damage: photoreactivation, excision repair, and post-replication repair. Photoreacti...